Dr. Julius No is a fictional character and the main antagonist in the 1958 James Bond novel and 1962 film Dr. No. The novel was adapted as the first official Bond film in 1962, the success of which would lead to a popular, long, and continuing series of films made by EON Productions. Dr. No is the sixth novel by the English author Ian Fleming to feature his British Secret Service agent James Bond.Fleming wrote the novel in early 1957 at his Goldeneye estate in Jamaica. He was portrayed by actor Joseph Wiseman in the 1962 film adaptation, where he was the first James Bond villain to appear in the EON Productions film series. It was first published in the United Kingdom by Jonathan Cape on 31 March 1958. The novel centres on Bond's investigation into the disappearance in Jamaica of two fellow MI6 operatives. Dr. No (sometimes published as Doctor No) is the sixth James Bond novel by Ian Fleming, originally published in 1958.